Quantum interference may lead to suppression and enhancement of the two-photon resonant nondegenerate fourwave mixing signal in a cascade four-level system. Such phenomena are demonstrated in Ba through inducing atomic coherence between the ground state 6s2 and the doubly excited autoionizing Rydberg state 6pnd. This method can be used as a new spectroscopic tool for measuring the transition dipole moment between two highly excited atomic states.