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近年来胃肠局部免疫特别是肠道上皮细胞与局部体液免疫及局部细胞.免疫之间关系的研究有很大进展,证实了由微生物和食物引起的感染和自然免疫,主要是通过胃肠道粘膜局部产生含有 J 链(Joining Chani)和分泌成份(Secretary Conponent,SC)的多聚体免疫球旦白 A 构成粘膜表面特殊的体液防御机制,即所谓的“粘膜免疫”或“粘膜表面屏障”,这意味着分泌型抗体在外环境中有特定的功能,是一种外分泌的免疫系统。分泌型免疫球旦白 A(SIgA)主要是由有分泌功能的粘膜局部产生,存在于许多外分泌液中,Tomasi 1965年最先提出 IgA
In recent years, great progress has been made in the study of the relationship between gastrointestinal local immunity, especially intestinal epithelial cells, and local humoral immunity and local cellular immunity. It is confirmed that microorganisms and food cause infections and innate immunity mainly through the gastrointestinal tract Mucosal local production of multimeric immunoglobulin A containing J chain (Joining Chani) and Secretary Conponent (SC) constitutes a particular humoral defense mechanism of the mucosal surface known as “mucosal immunity” or “mucosal surface barrier” , Which means that the secreted antibody has a specific function in the external environment and is an exocrine immune system. Secretory immunoglobulin A (SIgA) is produced locally by mucosal secretions and exists in many exocrine fluids. Tomasi first proposed IgA in 1965