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目的:探讨P16蛋白在子宫内膜癌发生和发展中的作用。方法:采用免疫组化法检测P16蛋白在30例增生期子宫内膜、28例单纯型增生过长、14例复杂型增生过长、10例非典型增生过长和50例子宫内膜癌中的表达。结果:在增生期子宫内膜、单纯型增生过长、复杂型增生过长、非典型增生过长和子宫内膜癌中P16的表达依次降低,子宫内膜癌中P16的表达与增生期子宫内膜相比,明显降低(P<0.05)。组织学分级G2+G3级中P16的阳性表达率明显低于G1级(P<0.05);有淋巴结转移组明显低于无淋巴结转移组(P<0.05)。结论:P16蛋白的表达与子宫内膜癌的发生发展密切相关,可作为子宫内膜癌的预后指标。
Objective: To investigate the role of P16 in the pathogenesis and progression of endometrial carcinoma. Methods: Immunohistochemical method was used to detect the expression of P16 protein in 30 cases of proliferative endometrium, 28 cases of simple hyperplasia, 14 cases of complicated hyperplasia, 10 cases of atypical hyperplasia and 50 cases of endometrial carcinoma expression. Results: The expression of P16 in proliferative endometrium, simple hyperplasia, complicated complex hyperplasia, atypical hyperplasia and endometrial carcinoma decreased in turn, the expression of P16 in endometrial carcinoma was significantly correlated with the expression of P16 in proliferative uterus Compared with the endometrium, it was significantly lower (P <0.05). The positive rate of P16 in G2 + G3 was significantly lower than that in G1 (P <0.05). The rate of P16 in lymph node metastasis was significantly lower than that in non-lymph node metastasis (P <0.05). Conclusion: The expression of P16 protein is closely related with the occurrence and development of endometrial carcinoma, which may be used as a prognostic indicator of endometrial cancer.