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选取我院2010年1月~2012年1月收治的46例耐多药和广泛耐药肺结核患者的临床资料,分析其耐药特点和原因,并对治疗效果进行分析。结果所有患者当中,获得性耐药患者37例(80.4%),其中中青年组获得性耐药20例,老年组获得性耐药6例,少年组获得性耐药11例;46例患者当中,经过常规治疗,胸片检查发现28例(60.9%)有吸收;9例(19.6%)有明显吸收;治愈患者25例,其中获得性耐药治愈18例,原发性耐药治愈7例。肝功能损害和药物性胃肠道反应为主要的不良反应。耐药肺结核治疗困难,治疗耐多药患者效果比治疗广泛耐药患者效果好,对患者进行耐药检测势在必行,并且要注意不同年龄阶段患者的耐药性检测,严格执行结核治疗周期,防止耐药患者和耐药菌株的出现。
The clinical data of 46 patients with MDR-MDR and extensively drug-resistant pulmonary tuberculosis admitted in our hospital from January 2010 to January 2012 were analyzed, their characteristics and causes of resistance were analyzed, and the treatment effect was analyzed. Results Of all the patients, 37 (80.4%) were acquired drug-resistant patients, including 20 cases of acquired resistance in middle-aged and young adults, 6 cases of acquired resistance in the elderly group and 11 cases of acquired resistance in the juvenile group. Among 46 cases After routine treatment, 28 cases (60.9%) were found to be absorbed by chest radiography; 9 cases (19.6%) had obvious absorption; 25 cases were cured, including 18 cases of acquired drug resistance and 7 cases of primary drug resistance . Liver damage and drug-induced gastrointestinal reactions as the main adverse reactions. Drug-resistant tuberculosis treatment is difficult, the treatment of multidrug-resistant patients than the effect of treatment of patients with extensive resistance is good, drug resistance testing in patients is imperative, and should pay attention to patients of different ages of drug resistance testing, strict implementation of TB treatment cycle , To prevent the emergence of drug-resistant patients and resistant strains.