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巨噬细胞在创伤愈合中起重要的作用。本实验以大鼠背部置入聚乙烯醇海绵的切口为模型，研究了６０Ｃｏγ射线６Ｇｙ全身照射后伤口巨噬细胞功能的变化和苯妥因钠的影响。结果表明在照射后３，５，８天的伤口不但巨噬细胞数明显下降，而且巨噬细胞的吞噬功能、ＴＮＦα和ＩＬ－１的释放都明显下降，而苯妥因钠对正常伤口和照射后的伤口的巨噬细胞数量及其功能都有明显的提高。说明了创伤愈合早期伤口巨噬细胞数量和功能的下降是照射造成愈合延迟的重要原因之一；苯妥因钠促进创伤愈合的作用与其提高巨噬细胞数量和功能有关。
Macrophages play an important role in wound healing. In this study, the incision of polyvinyl alcohol sponge in the back of rats was used as a model to study the changes of wound macrophage function after 6 Gy whole body irradiation with 60Coγ ray and the effect of phenytoin sodium. The results showed that the number of macrophages not only decreased obviously but also phagocytosis of macrophages and the release of TNFα and IL-1 in wounds 3, 5 and 8 days after irradiation, The number of macrophages after the wound and its function have been significantly improved. It is indicated that the decrease of the number and function of macrophages in the early stage of wound healing is one of the important reasons for the delayed healing of the wounds. The effect of phenytoin on wound healing is related to the increase of the number and function of macrophages.