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目的探究与分析人乳头瘤病毒16(HPV16)在宫颈癌前病变及宫颈癌中的检测及临床意义。方法选取新疆维吾尔自治区人民医院米东医院妇产科自2012年12月至2014年12月收治的宫颈癌前病变与宫颈癌患者95例,其中宫颈癌前病变60例,宫颈癌35例,分别作为癌前病变组与宫颈癌组,全部患者均经过严格操作后对其中HPV16进行检测。结果在宫颈癌前病变中,宫颈上皮内瘤变(CIN)Ⅱ级的阳性率明显高于CINⅠ级(χ~2=4.56,P<0.05),CINⅢ级的阳性率明显高于CINⅡ级(χ~2=5.24,P<0.05),宫颈癌组的阳性率明显高于宫颈癌前病变组(χ~2=6.88,P<0.05)。CINⅡ级的HPV16水平明显高于CINⅠ级(t=3.89,P<0.05),CINⅢ级的HPV16水平明显高于CINⅡ级(t=4.33,P<0.05),宫颈癌组的HPV16水平明显高于宫颈癌前病变组(t=5.21,P<0.05)。结论 HPV16感染是诱发宫颈癌前病变与宫颈癌的重要因素,对患者进行早期HPV16检测可有利于疾病的治疗与预防,有重要临床应用价值。
Objective To investigate and analyze the detection and clinical significance of human papillomavirus 16 (HPV16) in cervical precancerous lesions and cervical cancer. Methods 95 patients with cervical precancerous lesions and cervical cancer admitted from December 2012 to December 2014 in Obstetrics and Gynecology of Midong Hospital of People’s Hospital of Xinjiang Uygur Autonomous Region were enrolled. Among them, there were 60 cases of cervical precancerous lesions and 35 cases of cervical cancer, As a precancerous lesion group and cervical cancer group, all patients were tested for HPV16 after their strict operation. Results In cervical precancerous lesions, the positive rate of cervical intraepithelial neoplasia (CIN) was significantly higher than that of CINⅠ (χ ~ 2 = 4.56, P <0.05). The positive rate of CINⅢ was significantly higher than that of CINⅡ ~ 2 = 5.24, P <0.05). The positive rate of cervical cancer was significantly higher than that of cervical precancerous lesions (χ ~ 2 = 6.88, P <0.05). The level of HPV16 in CINⅡlevel was significantly higher than that in CINⅠlevel (t = 3.89, P <0.05). The level of HPV16 in CINⅢlevel was significantly higher than that in CINⅡlevel (t = 4.33, P <0.05) Precancerous lesions group (t = 5.21, P <0.05). Conclusion HPV16 infection is an important factor in inducing cervical precancerous lesions and cervical cancer. Early detection of HPV16 in patients is beneficial to the treatment and prevention of diseases, and has important clinical value.