单纯疱疹病毒Ⅰ型（ＨＳＶ－１）在角膜发生原发感染后可在三叉神经节（ＴＧ）及角膜组织内发生潜伏感染。分子生物学研究发现潜伏期ＴＣ及角膜组织中都存在ＨＳＶ－１的ＤＮＡ片段及特异性ＲＮＡ的转录，它们与ＨＳＶ－１的潜伏和复发有着密切的关系。但ＨＳＶ－１在ＴＧ与角膜内的潜伏机制有所不同，对这一问题的进一步研究将有助于对ＨＳＶ－１潜伏和复发机理的彻底阐明。 HSV-1 can cause latent infection in the trigeminal ganglion (TG) and corneal tissue after the primary corneal infection. Molecular biology study found that incubation of HSV-1 DNA fragment and specific RNA in both latent phase TC and corneal tissue exist, and they are closely related to the latent and recurrence of HSV-1. However, the potential mechanism of HSV-1 in TG and cornea is different. Further research on this issue will help to clarify the latent and recurrence mechanism of HSV-1.