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本文目的是观测慢性阻塞性肺疾病(COPD)伴肺动脉高压患者休息和运动时,甲巯丙脯酸联合氧疗对其肺血液动力学和气体交换的作用,并评价其临床意义。慢性支气管炎伴严重气道阻塞(FEV_1:0.4～1.3L)和持续低氧血症患者11例,皆接受长期氧疗5个月以上,均有肺动脉高压,6周内无病情恶化者,在吸氧情况下,分别于休息和运动时进行2次连续的肺血液动力学和动咏血气测定。第1次,口服甲巯丙脯酸12.5mg 后1小时进行。第2次,11例中的9例在用甲巯丙脯酸12.5mg,tid,治疗8周后进行。结果休息时,低流量氧疗可纠正低氧血症,但对肺血液动力学无明显影响,给予甲巯丙脯酸12.5mg 1次,除收缩期动脉压下降外,对肺动脉压
This article aims to observe the role of captopril combined with oxygen therapy in pulmonary hemodynamics and gas exchange during rest and exercise in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension, and evaluate its clinical significance. Chronic bronchitis with severe airway obstruction (FEV_1: 0.4-1.3L) and 11 patients with persistent hypoxemia received long-term oxygen therapy for more than 5 months, both had pulmonary hypertension and had no disease progression within 6 weeks In the case of oxygen inhalation, two consecutive pulmonary hemodynamics and MOA were performed during rest and exercise, respectively. The first time, oral captopril 12.5mg after 1 hour. The second, 9 of the 11 cases were treated with captopril 12.5 mg, tid, for 8 weeks. Results At rest, low-flow oxygen therapy could correct hypoxemia, but no significant effect on pulmonary hemodynamics, giving captopril 12.5mg once, in addition to decreased systolic arterial pressure, pulmonary arterial pressure