肺血管结构改建是缺氧性肺动脉高压(PHT)形成的重要基础,主要表现形式是中膜平滑肌的增殖及迁移,其中心环节是平滑肌细胞的增殖,而平滑肌细胞的增殖依赖于多种生长因子的作用,尤其是血小板衍生生长因子(PDGF)。本文就PDGF在缺氧性肺动脉平滑肌细胞增殖中的作用,综述如下。 Pulmonary vascular remodeling is an important basis for the formation of hypoxic pulmonary hypertension (PHT), the main manifestation is the proliferation and migration of smooth muscle in the media, the central part of which is the proliferation of smooth muscle cells, whereas the proliferation of smooth muscle cells depends on a variety of growth factors Especially platelet-derived growth factor (PDGF). This article on PDGF in hypoxic pulmonary artery smooth muscle cell proliferation, summarized as follows.