实验证明肿瘤内乏氧细胞对放射线和化疗药物有抗拒性,是导致根治肿瘤失败的重要因素。目前,已直接检测出动物肿瘤内存在乏氧细胞,人类肿瘤内含有乏氧细胞只是间接得到证实。直到八十年代,在乏氧细胞放射增敏剂作用机制得以深入阐明的基础上,才拉开人类肿瘤乏氧细胞显象研究的序幕。三十年来,乏氧细胞放射增敏剂的研究卓有 Experiments have shown that hypoxic cells in tumors are resistant to radiation and chemotherapeutic drugs, and are important factors in the failure of radical tumors. At present, hypoxic cells have been directly detected in animal tumors, and hypoxic cells in human tumors are only indirectly confirmed. It was only in the 1980s that the hypoxic cell radiosensitizers were fully elucidated and the prelude to imaging studies of hypoxic cells in human tumors was opened. Over the past 30 years, research on radiosensitizers for hypoxic cells