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目的 探讨雌激素 (estrogen ,EST)与血管瘤发生发展的关系。方法 采用免疫组化SP法检测了 38例血管瘤标本及 6例正常对照皮肤组织中EST、雌激素受体 (estrogenreceptor,ER)的表达。结果 毛细血管瘤EST表达增高 ,与海绵状和蔓状动脉瘤及正常皮肤组织间差异显著 ,尽管EST在海绵状和蔓状动脉瘤中表达高于正常对照组 ,但它们之间的差异无显著性意义 ;ER仅在部分毛细血管瘤组织中表达。EST和ER的表达均无性别间差异。结论 EST与毛细血管瘤的发展有密切关系 ,并为我们用药物治疗毛细血管瘤提供了理论依据。
Objective To investigate the relationship between estrogen (EST) and the occurrence and development of hemangiomas. Methods Immunohistochemical SP method was used to detect the expression of EST and estrogen receptor (ER) in 38 hemangiomas and 6 normal skin specimens. Results The expression of EST in capillary hemangioma was significantly higher than that in normal control group, although the expression of EST was higher in spongiform and vascularized aneurysms than in normal control group, but there was no significant difference between them Sexual significance; ER is only expressed in some of the capillary hemangiomas. There was no sex difference between EST and ER expression. Conclusion EST is closely related to the development of capillary hemangioma and provides a theoretical basis for the treatment of capillary hemangioma with drugs.