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目的 :了解枳木具子水提取液对四氯化碳致小鼠肝损伤的保护作用。方法 :在小鼠灌胃给予药液后 7d,腹腔注射四氯化碳 ,16 h后眼眶采血测定谷丙转氨酶 (ALT)、谷草转氨酶 (AST)、乳酸脱氢酶 (L DH)、胆固醇 (CH)、甘油三酯 (TG)等生化指标。通过比较药物组是否明显降低四氯化碳所致的生化指标异常升高 ,评价药物的保护作用。结果 :枳木具子水提取液明显降低四氯化碳所致的谷丙转氨酶、谷草转氨酶、乳酸脱氢酶等生化指标的异常升高。结论 :枳木具子水提取液对四氯化碳致小鼠肝损伤具有保护作用
Objective : To understand the protective effect of Aconitum comatus aqueous extract on carbon tetrachloride-induced liver injury in mice. METHODS: Seven days after the mice were intragastrically given the drug solution, intraperitoneal injection of carbon tetrachloride was performed. Sixteen hours later, blood samples were taken from the eyelids to determine ALT, AST, LDH, and cholesterol (ALT). CH), triglyceride (TG) and other biochemical indicators. By comparing whether the drug group significantly reduces the abnormal increase in biochemical indicators caused by carbon tetrachloride, the protective effect of the drug is evaluated. Results : The water extract of Aconitum japonica significantly reduced the abnormal increase of biochemical indexes such as alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase caused by carbon tetrachloride. Conclusion :The aqueous extract of Aconitum citrifolia has protective effect on liver injury induced by carbon tetrachloride in mice