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应用慢性埋植电极技术以电生理结合行为学的方法 ,在大鼠明暗分辨学习中 ,于每实验日训练前给DG微量注射 GABAb 受体拮抗剂 saclofen1 μl,观察此处理对海马 DG突触效应及行为习得的影响 ,结果表明 :较高浓度 (50 μmol/L)的 saclofen对 DG突触效应的习得性长时程增强 (Long- term potentiation,LTP)的形成有明显的抑制性影响 ,相应地阻抑明暗分辨学习的习得 ;加快习得性 LTP的消退 ,使行为消退加速。较低浓度 (2 5μmol/L)的 saclofen却易化习得性 LTP的形成 ,加快条件反射的建立 ;延缓习得性 LTP及行为的消退。提示 GABAb 受体在海马 DG习得性 LTP的形成与保持中有重要的调制作用 ,本文并就此予以讨论
The application of chronic implant electrode technology to electrophysiological and behavioral methods in the study of light and dark discrimination in rats, each experimental day before training DG microinjection of GABAb receptor antagonist saclofen1 l, observed that this treatment of hippocampal DG synaptic effect And behavioral acquisition. The results showed that saclofen at a higher concentration (50 μmol / L) had a significant inhibitory effect on the formation of long-term potentiation (LTP) of DG synaptic effect , Corresponding inhibition of light and dark learning learning acquisition; accelerate the extinction of learned LTP, so that the behavior subsided. Lower concentration (25μmol / L) of saclofen facilitated the formation of learned LTP, accelerated the establishment of conditioned reflex, and delayed the acquisition of acquired LTP and the regression of behavior. This suggests that GABAb receptor may play an important role in the formation and maintenance of DG-acquired LTP in hippocampus. This article discusses this