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作者观察了21例急性白血病患儿治疗前循环血中原始细胞、淋巴细胞、中性粒细胞和血小板酶活性(琥珀酸脱氢酶 SDG、甘油磷酸脱氢酶α-GPDG、乳酸脱氢酶 LDG)状态与临床表现的相互关系。11例为急性期,10例播散复发期。15例为急淋,2例为急粒,4例为未分化型。此时骨髓原始细胞广泛浸润,血中原始细胞占20～90%。在联合化疗前,细胞酶活性以原始细胞最高,其次为淋巴细胞和中性粒细胞,血小板酶活性最低。原始细胞的脱氢酶(SDG,α-GPDG、LDG)均显著高于淋巴细胞(P<0.01)。相关分析表明,白血病细胞和中性粒细胞之间的酶活性有明显的关联:同类脱氢酶之间、原始细胞的 SDG 和中性粒细胞的α-GPDG、原始细胞的α-GPDG 和中性粒细胞的 SDG 之间有正相关。白血病细胞的酶活性与疾病临床表现的显著性无相关关系。淋巴细胞的 SDG 活性和白细胞数、循环原始细胞数及α-GPDG 与原始细胞数之间有负相关,即淋巴细胞酶活性越高则疾病的临床表现越不明显。血小板 SDG 活性与循环原始细胞、出血症状呈
The authors observed the activity of protocells, lymphocytes, neutrophils, and platelet enzyme activity in precirculatory blood of 21 children with acute leukemia (succinate dehydrogenase SDG, glycerol phosphate dehydrogenase alpha-GPDG, lactate dehydrogenase LDG ) The relationship between state and clinical manifestations. 11 cases were acute and 10 cases recurred. 15 cases were acute leaching, 2 cases were acute granules, and 4 cases were undifferentiated. Bone marrow blast cells are extensively infiltrated at this time, and the original cells in the blood account for 20-90%. Before combined chemotherapy, cell enzyme activity was highest in primitive cells, followed by lymphocytes and neutrophils, and platelet enzyme activity was the lowest. The dehydrogenases (SDG, α-GPDG, LDG) of the original cells were significantly higher than those of lymphocytes (P<0.01). Correlation analysis showed a clear correlation between enzymatic activity between leukemia cells and neutrophils: between homologous dehydrogenases, primitive cell SDG and neutrophils, α-GPDG, protocell α-GPDG and There is a positive correlation between the SDGs of granulocytes. There was no correlation between the enzymatic activity of leukemic cells and the clinical manifestations of the disease. There is a negative correlation between lymphocyte SDG activity and leukocyte number, number of circulating blast cells, and α-GPDG and blast cells, that is, the higher the lymphocyte enzyme activity, the less obvious the clinical manifestation of the disease. Platelet SDG activity and circulating primitive cells, bleeding symptoms