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CD36是巨噬细胞表面的一种清道夫受体,是巨噬细胞吸收氧化低密度脂蛋白(OX-LDL)的主要受体。OX-LDL是导致动脉粥样硬化(AS)发生的重要物质。AS斑块中,80%的成分来源于摄取脂质的巨噬细胞和由其转化形成的泡沫细胞。巨噬细胞通过CD36摄取大量的OX-LDL形成泡沫细胞。抑制CD36的表
CD36 is a scavenger receptor on the surface of macrophages and is the main receptor for macrophages to absorb oxidized low density lipoprotein (OX-LDL). OX-LDL is an important substance that causes atherosclerosis (AS). Of the AS plaques, 80% of the components are derived from lipid-uptake of macrophages and foam cells transformed by them. Macrophages uptake large amounts of OX-LDL through CD36 to form foam cells. CD36 inhibition table