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目的探讨系统性红斑狼疮（ＳＬＥ）患者血清泌乳素（ＰＲＬ）与性激素水平的关系。方法检测３１例ＳＬＥ患者ＰＲＬ、雌二醇（Ｅ２）及睾酮（Ｔ）水平。结果ＳＬＥ患者平均ＰＲＬ水平较对照组明显升高（Ｐ＜０．０１），以活动期患者升高更为显著（Ｐ＜０．０１），同时活动期患者Ｅ２水平较对照组升高（Ｐ＜０．０５），３１例患者Ｔ水平均明显下降，与对照组比较有非常显著性差异（Ｐ＜０．０１），Ｅ２／Ｔ显著升高，血清ＰＲＬ水平与活动期患者Ｅ２水平呈正相关。结论ＰＲＬ与ＳＬＥ的发病与病情活动密切相关，可能与雌激素分泌异常有关，而雄激素有维护免疫系统的正常功能。
Objective To investigate the relationship between serum prolactin (PRL) and sex hormones in patients with systemic lupus erythematosus (SLE). Methods The levels of PRL, estradiol (E2) and testosterone (T) in 31 SLE patients were detected. Results The average level of PRL in patients with SLE was significantly higher than that in control group (P <0.01), and was significantly higher in active patients (P <0.01). Meanwhile, the level of E2 in active patients was higher than that in control group (P (P <0.01). E2 / T was significantly increased, serum prolactin level was positively correlated with E2 level in patients with active disease (P0.05) .There was a significant difference between the two groups . Conclusions The incidence of PRL and SLE is closely related to the disease activity, which may be related to the abnormal estrogen secretion. Androgen has the normal function of maintaining the immune system.