寄生蠕虫的感染可诱导产生针对碳水化合物抗原的体液免疫应答,提示该类抗原可用于疫苗或新的血清学诊断方法的研究。已证实,血吸虫中的聚糖可作为宿主体液免疫应答的主要靶抗原。为鉴定聚糖分子中的抗原性片段,已对血吸虫的糖蛋白和糖脂中的聚糖结构进行了大量研究。但对直接决定其抗原性的糖链组成和结构目前尚知之甚少,限制了此类研究的进一步发展。 Infection with parasitic worms induces a humoral immune response against carbohydrate antigens, suggesting that such antigens may be useful in vaccine or new serological diagnostic methods. It has been demonstrated that glycans in Schistosoma japonicum can serve as the primary target antigen for host humoral immune responses. In order to identify antigenic fragments in glycan molecules, a great deal of research has been conducted on the glycoproteins of schistosoma and glycan structures in glycolipids. However, little is known about the composition and structure of sugar chains that directly determine their antigenicity, which limits the further development of such studies.