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目的分析吸烟与否对慢性阻塞性肺疾病急性加重期患者血中C-反应蛋白及白细胞(WBC)计数的影响。方法将我院门诊及住院处自2006年12月至2010年11月期间收治的111例慢性阻塞性肺疾病急性加重期患者根据吸烟史将其分成吸烟组33例、戒烟组36例及无烟组42例,对患者的血清CRP进行测定,并计数外周血白细胞(WBC)。结果三组患者间的CRP浓度与WBC计数结果比较,差异均不显著(P均>0.05),不具有统计学意义。三组患者CRP上升率对比差异不显著(P=0.226,OR=1.21),即吸烟(包括戒烟者在内)对慢性阻塞性肺疾病急性加重期患者血清CRP上升没有影响。慢性阻塞性肺疾病急性加重期患者血中CRP浓度与WBC计数表现为正相关关系(r=0.302,P<0.05)。结论吸烟、戒烟及非吸烟的慢性阻塞性肺疾病急性加重期患者CRP均无显著差异,CRP同吸烟与否无关,但与感染有一定的关联。
Objective To analyze the influence of smoking on the count of C-reactive protein and white blood cell (WBC) in patients with acute exacerbation of chronic obstructive pulmonary disease. Methods A total of 111 patients with COPD exacerbation from December 2006 to November 2010 were divided into smoking group (33 cases), smoking cessation group (36 cases) and non-smoking group Group of 42 patients, the patient’s serum CRP was measured, and count the number of peripheral white blood cells (WBC). Results There was no significant difference between the three groups in CRP concentration and WBC count (P> 0.05), which was not statistically significant. There was no significant difference in the rate of increase of CRP between the three groups (P = 0.226, OR = 1.21). That is, smoking (including smoking cessation) had no effect on the increase of serum CRP in patients with acute exacerbation of chronic obstructive pulmonary disease. There was a positive correlation between CRP concentration and WBC count in patients with acute exacerbation of COPD (r = 0.302, P <0.05). Conclusion There was no significant difference in CRP between smoking, smoking cessation and non-smoking chronic obstructive pulmonary disease in patients with acute exacerbation. CRP was not related with smoking or not, but it was associated with infection.