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目的:研究肝细胞癌螺旋CT增强表现与血浆VEGF水平的相关性。方法:选择病理确诊的肝细胞癌患者57例和40名正常健康人,比较两者血浆VEGF值的差异;回顾性分析肝细胞癌患者螺旋CT增强后影像学特征(包括病灶形态、大小、包膜、强化特征、有无癌栓和淋巴结转移)与血浆VEGF水平的相关性,并进行统计分析。结果:肝细胞癌组与正常组VEGF均值分别为(234.39±46.63)和(108.46±34.59)μg/L,差异有统计学意义,P<0.05。肝细胞肝癌螺旋CT增强表现中,肿瘤形态、包膜是否完整、强化特征、是否有癌栓和淋巴结转移情况与患者血浆VEGF水平有关,P均<0.05。肿瘤的大小与VEGF水平无关,P>0.05。结论:肝细胞癌螺旋CT增强后良、恶性征象与血浆VEGF水平存在相关性,恶性程度高,血浆VEGF值就越高,故检测血浆VEGF值可初步了解肝癌的恶性程度。
Objective: To study the correlation between enhanced spiral CT findings and plasma VEGF levels in hepatocellular carcinoma. Methods: Fifty-seven patients with pathologically diagnosed hepatocellular carcinoma and 40 healthy controls were enrolled in this study. The differences in plasma VEGF between the two groups were compared. The imaging features (including lesion morphology, size, Membrane, enhanced features, with or without tumor thrombus and lymph node metastasis) and plasma VEGF levels, and statistical analysis. Results: The mean VEGF levels were (234.39 ± 46.63) and (108.46 ± 34.59) μg / L in hepatocellular carcinoma and normal group, respectively, with statistical significance (P <0.05). The enhancement of spiral CT in hepatocellular carcinoma showed that the morphology of tumor, the integrity of capsule, the enhancement of features, the presence of tumor emboli and lymph node metastasis were related to the level of plasma VEGF in patients with hepatocellular carcinoma (all P <0.05). Tumor size has nothing to do with the level of VEGF, P> 0.05. Conclusion: There is a correlation between benign and malignant signs of hepatocellular carcinoma and plasma VEGF levels after enhanced spiral CT. The degree of malignancy is high and the plasma VEGF value is higher. Therefore, the detection of plasma VEGF value can initially understand the malignant degree of liver cancer.