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松弛素为分子量6000D的胰岛素样多肽类激素,除参与妊娠、分娩、扩张产道等作用外,尚具有心血管效应,如心肌变时变力效应,舒血管、调节血管张力、降低血压、增加冠脉流量的血管效应,抑制血小板聚集的血液效应,尚可抑制细胞增殖和细胞外基质如胶原的合成等,与一氧化氮的血管效应相平行。提示,松弛素可能部分通过一氧化氮介导而发挥作用。松弛素对心血管系统作用的一氧化氮机制在心血管疾病治疗中有潜在的意义。
Relaxin is a molecular weight 6000D of insulin-like peptide hormones, in addition to participation in pregnancy, childbirth, expansion of the birth canal and other effects, but also have cardiovascular effects, such as myocardial variable time-effect, relax blood vessels, regulate vascular tone, lower blood pressure, Vascular effects of blood flow, inhibition of blood platelet aggregation effect, can inhibit cell proliferation and extracellular matrix, such as collagen synthesis, and vascular effects of nitric oxide in parallel. Tip, relaxin may be partially mediated by nitric oxide to play a role. The mechanism of relaxin on the cardiovascular system of nitric oxide in the treatment of cardiovascular disease has potential significance.