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Objective: To explore the clinical significance of the examination of serum CA125 level of patients with metastatic bladder carcinoma.Methods: Electrochemiluminescance technique was used to examine the serum CA125 concentration of 58 cases with metastatic bladder cancer.30 cases of superficial bladder cancer and 8 cases of other urological diseases were collected as the control group.Results: Serum CA125 level in 39 (67.2%) out of 58 cases ranged from 36.7 U/mL to 1485.6 U/mL (mean 498.3 U/mL), being higher than normal (＜35 U/mL).Serum CA125 level of metastatic bladder cancer patientswas 324.5 U/mL, significantly higher than that in control group (P＜0.001).Serum CA125 level of 10 patients after transurethral resection operation was significantly lower than that before operation (P＜0.05).Serum CA125 level of 16 patients whorefused further treatment significantly increased from 450.4 U/mL, to 505.8 U/mL (P = 0.041) 3 months after discharge from the hospital.Serum CA125 level of 17 patients significantly decreased from 475.8 U/L to 237.9 U/mL (P＜0.001 ) after bilaterallilac-arterial embolism treatment.Conclusion: CA125 may be a valuable marker for the judgment of advanced metastatic bladder cancer.