肿瘤细胞对抗癌药物产生耐受性是肿瘤化学治疗的主要障碍。而 p53作为一种重要的抑癌基因，能通过调控相关基因，参与肿瘤细胞的代谢、细胞周期阻滞、细胞凋亡等过程，而多种相关因子亦能作用于p53基因，对肿瘤耐药性具有重要的影响。随着p53与肿瘤耐药的调控因子及可能机制研究的深入，为利用p53逆转肿瘤耐药性治疗的进一步研究提供思路。“,”Drug resistance is the main obstacle of chemotherapy in the treatment of cancer .As an impor-tant tumor suppressor gene, p53 gene is able to regulate related genes to participate in tumor progression including tumor metabolism,cell cycle arrest and apoptosis,and variety of related factors can also act on the p53 gene,playing an important role in tumor drug resistance.The progress in the study of the regulatory fac-tors and possible mechanisms of p53 and tumor resistance provides ideas of using p53 gene to reverse drug resistance of human cancer.