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目的观察多西他赛联合表阿霉素治疗晚期乳腺癌的疗效及其毒副作用。方法应用多西他赛联合表阿霉素治疗晚期乳腺癌36例,其中初始治疗者30例,复发或出现转移再治疗者6例。按21d为一个周期,行4～6个周期化疗后对患者的症状,瘤体大小及毒副作用进行总结评价。结果 36例患者中,5例完全缓解,19例部分缓解,4例处于病情稳定,8例病情出现进展。临床有效率66.7%,临床获益率达77.8%。毒副反应主要以胃肠道反应和骨髓抑制为主,多为Ⅰ～Ⅱ度。结论国产多西他赛联合表阿霉素治疗晚期乳腺癌有较好的疗效,而且毒副反应轻,可作为晚期乳腺癌的首选化疗方案。
Objective To observe the efficacy and side effects of docetaxel combined with epirubicin in the treatment of advanced breast cancer. Methods The application of docetaxel in combination with epirubicin in the treatment of advanced breast cancer in 36 cases, of which initial treatment in 30 cases, recurrence or metastasis and re-treatment in 6 cases. According to 21d as a cycle, 4 to 6 cycles of chemotherapy after the patient’s symptoms, tumor size and toxicity were evaluated. Results Of the 36 patients, 5 were completely relieved, 19 were partially relieved, 4 were stable, and 8 showed progression. Clinical efficiency 66.7%, clinical benefit rate of 77.8%. The main side effects of gastrointestinal reactions and bone marrow suppression, mostly Ⅰ ~ Ⅱ degrees. Conclusion domestic docetaxel combined with epirubicin in the treatment of advanced breast cancer has a good effect, and mild side effects, can be used as the preferred chemotherapy for advanced breast cancer.