论文部分内容阅读
目的:探讨小剂量胺碘酮与贝那普利联合治疗心功能正常的阵发性心房颤动(PAF)的临床疗效。方法:将41例PAF随机分为胺碘酮组(对照组21例)和胺碘酮加贝那普利组(治疗组20例),治疗随访时间为1年。观察2组窦性心律维持率和左心房内径变化。结果:2组治疗前后12个月间左心房内径差异显著(P<0.05);治疗后第2、4、6、8个月,对照组组窦性心律的维持率低于治疗组,但差异无统计学意义,治疗10、12个月后,2组间差异有统计学意义(P<0.05)。结论:胺碘酮与贝那普利联合治疗心功能正常的PAF维持窦性心律的疗效优于单用胺碘酮,贝那普利可以延缓左心房的扩大。
Objective: To investigate the clinical efficacy of low dose amiodarone combined with benazepril in the treatment of paroxysmal atrial fibrillation (PAF) with normal cardiac function. Methods: 41 cases of PAF were randomly divided into amiodarone group (21 cases in control group) and amiodarone plus benazepril group (20 cases in treatment group). The follow-up time was 1 year. The maintenance rate of sinus rhythm and the change of left atrial diameter were observed in two groups. Results: There was significant difference in the left atrial diameter between the two groups before and after 12 months (P <0.05). At the 2nd, 4th, 6th and 8th month after treatment, the maintenance rate of sinus rhythm in the control group was lower than that in the treatment group No statistical significance. After treatment for 10 and 12 months, the difference between the two groups was statistically significant (P <0.05). Conclusions: The combination of amiodarone and benazepril in the treatment of PAF with normal cardiac function is better than amiodarone in maintaining sinus rhythm. Benazepril can delay the enlargement of the left atrium.