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目的探讨绝经后轻、中度压力性尿失禁患者应用雌激素联合生物反馈电刺激治疗的效果。方法绝经后轻、中度压力性尿失禁患者59例,随机分为观察组30例和对照组29例。对照组给予生物反馈电刺激治疗,2次/周,共10次;观察组生物反馈电刺激治疗方法同对照组,并于每次治疗后阴道壁涂抹雌三醇软膏0.5g。分别于治疗前及治疗3、6个月后行1h尿垫实验统计漏尿量;填写尿失禁问卷表简表(International Consultation Committee on urinary incontinence questionnaire short form scale,ICI-Q-SF);行盆腔彩超检查测量子宫内膜厚度,并进行比较。结果治疗3、6个月后,观察组漏尿量[(4.97±1.38)、(5.98±1.07)g]、ICI-Q-SF评分[(4.01±1.48)、(5.94±1.27)分]均较治疗前[(8.70±2.03)g、(8.70±2.72)分]下降(P<0.05);对照组漏尿量[(6.04±1.19)g、(6.13±0.85)g]、ICI-Q-SF评分[(5.95±1.61)、(5.98±1.49)分]均较治疗前[(9.10±2.17)g、(8.90±2.31)分]下降(P<0.05);观察组治疗3个月后漏尿量、ICI-Q-SF评分低于对照组,差异有统计学意义(P<0.05);2组治疗3、6个月后子宫内膜厚度与治疗前比较差异均无统计学意义(P>0.05),且组间比较差异均无统计学意义(P>0.05)。结论与单纯生物反馈电刺激治疗相比,雌激素联合生物反馈电刺激治疗可缓解绝经后女性轻、中度压力性尿失禁,不影响子宫内膜厚度,随时间延长,2种方法治疗效果相近。
Objective To investigate the effect of estrogen combined with biofeedback stimulation in post-menopausal patients with mild or moderate stress urinary incontinence. Methods 59 cases of mild and moderate stress urinary incontinence after menopause were randomly divided into observation group (30 cases) and control group (29 cases). The control group was treated with biofeedback stimulation twice a week for 10 times. The biofeedback stimulation in the observation group was treated with the same method as the control group, and 0.5 g of estriol ointment was smeared on the vaginal wall after each treatment. The urinary incontinence was calculated on the 1-hour urine pad before treatment and 3 and 6 months after treatment respectively. The International Consultation Committee on urinary incontinence questionnaire short form scale (ICI-Q-SF) Color Doppler ultrasound measurements of endometrial thickness, and compared. Results After 3 and 6 months of treatment, the amount of urine leakage in the observation group was significantly lower than that in the observation group [(4.97 ± 1.38), (5.98 ± 1.07) g], ICI-Q-SF score [(4.01 ± 1.48), (5.94 ± 1.27) (P <0.05). The amount of urine leakage in the control group [(6.04 ± 1.19) g, (6.13 ± 0.85) g] and ICI-Q- (P <0.05); SF score [(5.95 ± 1.61), (5.98 ± 1.49) points compared with before treatment [(9.10 ± 2.17) g, (8.90 ± 2.31) points] Urine output and ICI-Q-SF score were lower than those in the control group (P <0.05). There was no significant difference in endometrial thickness between the two groups at 3 and 6 months after treatment > 0.05), and there was no significant difference between the two groups (P> 0.05). Conclusions Compared with mere biofeedback stimulation, estrogen combined with biofeedback stimulation can relieve mild and moderate stress urinary incontinence in postmenopausal women without affecting the thickness of endometrium. With the prolongation of time, the two methods have similar treatment effect .