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骨髓间充质干细胞(BMDCs)形成胃癌是近年来新发现的一种新现象,给胃癌研究带来极大启发。关于胃癌起源主要有两种观点:传统观念认为胃癌来源于胃黏膜上皮细胞恶性转变;近年来观点认为胃癌起源于胃肠道肿瘤干细胞。BMDCs形成胃上皮癌,使胃癌的起源有了第三种新的可能性:胃癌来源于BMDCs。这对传统观念产生很大挑战性和冲击性,对胃癌/肿瘤的研究有重要意义。本文对此问题近年来的相关研究进展做一综述。
The formation of gastric cancer by bone marrow mesenchymal stem cells (BMDCs) is a new phenomenon newly discovered in recent years, which brings great inspiration to gastric cancer research. On the origin of gastric cancer there are two main points: the traditional view that gastric cancer stems from malignant transformation of gastric mucosal epithelial cells; recent point of view that gastric cancer originated in gastrointestinal cancer stem cells. BMDCs form gastric epithelial carcinomas, which have a third new possibility for the origin of gastric cancers: gastric carcinomas originate from BMDCs. This has a great challenge to the traditional concepts and impact on gastric cancer / tumor research is of great significance. This article reviews the progress made in this issue in recent years.