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目的探讨N-端脑利钠肽前体(NT-proBNP)在妊娠高血压疾病(PIH)心功能评估中的价值。方法将102例PIH孕妇分为妊娠高血压组37例,轻度子痫前期组33例,重度子痫前期组32例,另外选取正常妊娠组32例及正常未孕育龄妇女32例作为对照组,采用电化学发光法测定患者血清NT-proBNP浓度。结果 PIH组、正常妊娠组和对照组的NT-proBNP水平分别为(300.52±134.44)、(83.42±26.26)和(59.83±12.89)pg/ml,三者间比较差异均有统计学意义(P<0.01)。重度子痫前期组、轻度子痫前期组、妊娠高血压组的NT-proBNP水平分别为(488.56±155.54)、(323.39±148.90)和(185.73±43.78)pg/ml,三者间比较差异均有统计学意义(P<0.01)。NT-proBNP与孕妇体重指数(BMI)呈正相关(r=0.602),与新生儿体重呈负相关(r=-0.279)。结论孕后NT-proBNP有所升高,而且是能够用于评估PIH孕妇心功能的敏感指标之一。
Objective To investigate the value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the assessment of cardiac function in pregnancy-induced hypertension (PIH). Methods A total of 102 PIH pregnant women were divided into 37 cases of pregnancy-induced hypertension, 33 cases of mild preeclampsia and 32 cases of severe preeclampsia. In addition, 32 cases of normal pregnancy and 32 cases of non-pregnant women were selected as control group The serum NT-proBNP concentration was measured by electrochemiluminescence. Results NT-proBNP levels in PIH group, normal pregnancy group and control group were (300.52 ± 134.44), (83.42 ± 26.26) and (59.83 ± 12.89) pg / ml, respectively <0.01). The levels of NT-proBNP in severe preeclampsia group, mild preeclampsia group and gestational hypertension group were (488.56 ± 155.54), (323.39 ± 148.90) and (185.73 ± 43.78) pg / ml, respectively All were statistically significant (P <0.01). NT-proBNP was positively correlated with the body mass index (BMI) of pregnant women (r = 0.602), and negatively correlated with the weight of newborns (r = -0.279). Conclusion NT-proBNP increased after pregnancy, and it is one of the sensitive indicators that can be used to evaluate the cardiac function of pregnant women with PIH.