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This study investigated whether high-normal thyrotropin(TSH) levels are associated with metabolic syndrome in euthyroid Chinese people≥40 years old.Clinical and metabolic factors were assessed in 2,356 subjects(40-77 years old) with TSH levels in the normal range(0.35-5.00 mU/L).Using 2.50 mU/L as the cut-off point of TSH level within the normal range,we divided subjects into the high-TSH(2.50-5.00 mU/L;n= 1,064) and low-TSH(0.35-2.50mU/L;n= 1,292) group.The results showed that the mean levels of body mass index(BMI),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),and fasting plasma glucose(FPG) were higher in the high-TSH group and TSH levels were significantly positively con-elated with BMI,LDL-C,TC,and FPG.The prevalence of central obesity,hypertriglyceridemia,low high density lipoprotein cholesterol(HDL-C),and high FPG(>5.60 mmol/L) was significantly higher in females and subjects with high-TSH levels.Metabolic syndrome was also more prevalent in the high-TSH group.People over the age of 40 years with high-normal TSH levels had a 1.2-fold increased risk of metabolic syndrome,compared with those with low-normal TSII levels,after adjusting for age and gender.In conclusion,high normal TSH is a risk factor for metabolic syndrome in people ≥40 years old.
This study investigates whether high-normal thyrotropin (TSH) levels are associated with metabolic syndrome in euthyroid Chinese people ≥ 40 years old. Clinical and metabolic factors were assessed in 2,356 subjects (40-77 years old) with TSH levels in the normal range ( 0.35-5.00 mU / L). Using 2.50 mU / L as the cut-off point of TSH level within the normal range, we divided subjects into the high-TSH (2.50-5.00 mU / L; n = 1,064) and low- TSH (0.35-2.50 mU / L; n = 1,292) group. The results showed that the mean levels of body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL- (FPG) were higher in the high-TSH group were significantly positively con-elated with BMI, LDL-C, TC, and FPG. Prevalence of central obesity, hypertriglyceridemia, low high density lipoprotein cholesterol (HDL-C) , and high FPG (> 5.60 mmol / L) were significantly higher in females and subjects with high-TSH levels. Metabolic syndrome was also more prevalent in the high-TSH gro People over the age of 40 years with high-normal TSH levels had a 1.2-fold increased risk of metabolic syndrome, compared with those with low-normal TSII levels, after adjusting for age and gender. In conclusion, high normal TSH is a risk factor for metabolic syndrome in people ≥40 years old.