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骨桥蛋白(osteopontin,OPN)是分泌型磷酸糖蛋白,它广泛存在于包括生殖系统在内的多 种组织器官中,在细胞的增殖、分化、黏附和迁移中起重要作用。OPN是受孕激素调控并在胚胎 着床和胎盘形成中起重要作用的一种细胞外基质,与妊娠成功地建立和维持密切相关。
Osteopontin (OPN) is a secreted phosphoglycoprotein. It widely exists in many tissues and organs including the reproductive system and plays an important role in cell proliferation, differentiation, adhesion and migration. OPN is an extracellular matrix that is regulated by progestin and plays an important role in embryo implantation and placenta formation. It is closely related to the successful establishment and maintenance of pregnancy.