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目的:探讨卵巢恶性生殖细胞肿瘤的治疗疗效及复发患者二线治疗。方法:对我院1958年11月～1998年12月312例卵巢恶性肿瘤中的154例接受顺铂方案化疗的卵巢恶性生殖细胞肿瘤结果进行分析。结果:154例卵巢恶性生殖细胞肿瘤的总生存率为74.7%,初治患者(Ⅰ～Ⅲ期)92例,5年生存率为92.2%,其中66例(71.7%)保留生育功能,19例已正常生育20次。复发转移62例,5年生存率51.1%,8例保留生育功能。结论:为了提高卵巢恶性生殖细胞肿瘤生存率,首次手术时应正确分期,术后及时采用当前标准BEP方案作为一线化疗,连续3～6疗程。对复发患者,根据以往治疗情况尽早选用有效的二线方案化疗,有利于提高生存率。
Objective: To investigate the therapeutic effect of ovarian malignant germ cell tumors and second-line treatment of relapsed patients. Methods: In our hospital from November 1958 to December 1998 312 cases of ovarian cancer in 154 cases of cisplatin regimen of ovarian malignant germ cell tumors were analyzed. Results: The overall survival rate of 154 ovarian malignant germ cell tumors was 74.7%. 92 patients were newly diagnosed (stage Ⅰ ~ Ⅲ), the 5-year survival rate was 92.2%, of which 66 (71.7%) retained fertility and 19 Has been normal birth 20 times. 62 cases of recurrence and metastasis, 5-year survival rate of 51.1%, 8 cases of reproductive function. Conclusion: In order to improve the ovarian malignant germ cell tumor survival rate, the first operation should be the correct staging, timely use of the current standard BEP regimen as first-line chemotherapy for 3 to 6 courses. Recurrence of patients, according to the treatment of early selection of effective second-line chemotherapy, is conducive to improving the survival rate.