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用林县粮食中分离的串珠镰刀菌和半裸镰刀菌分别发霉食物,用Wistar大鼠进行诱癌实验。实验结果:1.串珠镰刀菌组,动物喂饲霉食247～956天、30只动物中发现乳腺癌肉瘤1例,腹腔和纵隔网织细胞型淋巴肉癌3例,结肠乳头状癌1例,肿瘤总发生率为16.7％(5/30)。食管上皮增生发生率6.7％(2/30),前胃上皮为3.3％(1/30);2.半裸镰刀菌组,动物喂饲霉食65～648天、20只动物中发现腹腔网织细胞型淋巴肉瘤、膀胱乳头状瘤各1例,肿瘤总发生率为10％(2/20)。前胃上皮底层细胞增生2例,其中1例并有脐样病灶形成;3.对照组,动物喂饲未经发霉处理的正常饲料157～844天,32只动物中未发现任何肿瘤。两个实验组的大鼠肺脓肿和肺部慢性肉芽肿的展生率均高于对照组,结果提示这两种霉菌对肺脏亦有致病性。
Fusarium brevifolia and semi-naked Fusarium spp. isolated from the grain of Linxian County were used to produce moldy foods and Wistar rats were used to induce cancer. Experimental results: 1. Fusarium moniliforme group, animals fed moldy food for 247-956 days, 30 cases found in breast cancer sarcoma in 1 case, abdominal and mediastinal reticulocyte-type lymphoma cancer in 3 cases, 1 case of colonic papillary carcinoma The overall incidence of tumors was 16.7% (5/30). The incidence rate of esophageal epithelial hyperplasia was 6.7% (2/30), and the pregastric epithelium was 3.3% (1/30); 2. The semi-naked Fusarium group, the animals were fed mildew for 65 to 648 days, and 20 animals were found to have abdominal reticulum There were 1 case of lymphosarcoma of the cell type and 1 case of papilloma of the bladder. The total incidence of tumors was 10% (2/20). Prostatic gastric epithelial cells proliferated in 2 cases, and 1 case had umbilical-like lesions. 3. In the control group, the animals were fed normal mildew-free diet for 157 days to 844 days. No tumors were found in 32 animals. In the two experimental groups, the rates of lung abscess and pulmonary chronic granuloma in rats were higher than those in the control group. The results suggest that the two molds are also pathogenic to the lungs.