本文应用高效液相色谱法测定血浆心得安浓度,并研究一组健康志愿者静脉注射心得安的药代动力学特点,结果显示本组人群的药代动力学特点与国外报导的相似。半衰期为3.15小时,血浆清除率为72.319L/h,表观分布容积为3.946L/Kg。相当一部分人接受5mg心得安静注后,峰值血药浓度明显升高,提示临床静脉用药时用量宜偏小。 In this paper, plasma concentration of propranolol was determined by HPLC, and the pharmacokinetics of propranolol was studied in a group of healthy volunteers. The results showed that the pharmacokinetics of this group were similar to those reported in foreign countries. Half-life of 3.15 hours, the plasma clearance rate of 72.319L / h, the apparent volume of 3.946L / Kg. A considerable number of people receiving 5mg experience after the quiet note, the peak plasma concentration was significantly increased, suggesting that the amount of clinical intravenous medication should be small.