胃泌素释放肽受体GRPR为BLP受体家族中的一员,属于G蛋白耦联受体,因其在肿瘤组织中具有重要的生长效应而倍受关注。研究证实:GRPR在多种人类肿瘤的发生、发展、浸润等方面发挥重要作用。随着对GRPR的研究不断深入,其在妇科肿瘤早期发现、诊断、治疗中的应用也日益广泛。就GRPR结构分布、在肿瘤细胞中的信号传导通路、在妇科肿瘤中的作用及诊断、治疗方面的研究现状做文献综述。 Gastrin-releasing peptide receptor GRPR, a member of the BLP receptor family, belongs to the G protein-coupled receptor and attracts much attention because of its important growth effect in tumor tissues. Studies have shown that: GRPR plays an important role in the occurrence, development and invasion of many human tumors. With the continuous research of GRPR, its application in the early detection, diagnosis and treatment of gynecological tumors is also increasingly widespread. The distribution of GRPR, signal transduction pathways in tumor cells, the role in the diagnosis of gynecologic oncology and diagnosis and treatment of the literature review.