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目的:观察叶酸对H型高血压患者颈动脉粥样硬化与左心室肥厚(LVH)的影响。方法:对100例H型高血压LVH患者随机分组:叶酸组50例,对照组50例;在治疗前及叶酸治疗3个月、6个月后应用彩色多普勒超声观察患者颈动脉粥样硬化情况及LVH指标变化。结果:12组患者经治疗后收缩压(SBP)、舒张压(DBP)均有显著降低(P<0.05),且叶酸组降压效果更明显;2叶酸组在治疗前后颈动脉的内中膜厚度(IMT)比较差异有统计学意义(P<0.05),且与对照组比较亦明显降低,差异有统计学意义(P<0.05),对照组治疗前后IMT比较差异无统计学意义(P>0.05);32组治疗后左室舒张早期二尖瓣血流峰速度(E)与晚期血流峰速度(A)的比值(E/A)、左室射血分数(LVEF)值与治疗前比较均显著升高(P<0.05),治疗后2组患者间E/A值、LVEF值比较均差异有统计学意义(均P<0.05),且叶酸组升高效果更明显。结论:应用叶酸干预治疗,可以更好地改善H型高血压患者颈动脉粥样硬化程度及左心功能。
Objective: To observe the effect of folic acid on carotid atherosclerosis and left ventricular hypertrophy (LVH) in patients with Hypertension. Methods: One hundred patients with hypertensive LVH were randomly divided into five groups: 50 patients in the folic acid group and 50 patients in the control group. Carotid atherosclerosis was observed by color Doppler ultrasonography in 3 months and 3 months after treatment. Hardening and changes in LVH indicators. Results: After treatment, SBP and DBP were significantly decreased in both groups (P <0.05), and the depressor effect was more obvious in folic acid group. In the two folic acid groups, the carotid intima-media There was significant difference in IMT between the two groups (P <0.05), and there was significant difference between the two groups (P <0.05). There was no significant difference in IMT between the two groups before and after treatment (P> 0.05). The values of E / A and LVEF in early post-treatment and post-treatment (P <0.05). There was significant difference in E / A value and LVEF value between the two groups after treatment (all P <0.05), and the folic acid group increased more obviously. Conclusion: The application of folic acid intervention can better improve the degree of carotid atherosclerosis and left ventricular function in patients with Hypertension.