论文部分内容阅读
本文观察了5-FU对孕鼠、胚胎的毒性,发现随剂量的增加毒性增强,孕鼠、胚胎体重减轻、生长迟缓,胚胎吸收率增加。若同时给维生素C、叶酸,不仅不能使5-FU的毒性减轻,反而使其毒性增加,胚胎吸收率及血清球蛋白升高,胚胎存活率、胚胎正常发育率、血清白蛋白及白/球比值均降低。结果表明维生素C、叶酸与5-FU合并用药可明显增强5-FU的毒性。
In this paper, the toxicity of 5-FU to pregnant rats and embryos was observed. The toxicity of 5-FU to pregnant mice and embryos was observed. The toxic effects of 5-FU on pregnant mice and embryos were observed. The pregnant rats and embryos lost weight, grew slowly and their embryo absorptivity increased. If at the same time to vitamin C, folic acid, not only can not reduce the toxicity of 5-FU, but to increase their toxicity, increased embryonic absorption and serum globulin, embryonic survival, embryonic normal development, serum albumin and white / ball The ratio is lower. The results show that vitamin C, folic acid combined with 5-FU can significantly enhance the toxicity of 5-FU.