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目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)合并血小板减少的原因及临床处理方法。方法回顾分析我科2010年至2014年间60例AECOPD患者合并血小板减少患者临床资料。结果 50%无需特殊升血小板治疗,30%给予糖皮质激素及预防出血处理,15%加用重组人白介素II(巨和粒)升血小板,5%需要进一步输注新鲜血小板治疗。对于出现局部皮下出血的患者及时停用可能导致血小板减少的一切药物。结论虽然AECOPD患者住院治疗期间导致血小板减少的原因、机制不明确,从本组病例的分析得出与药源性、感染性有一定相关性。
Objective To investigate the causes and clinical treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with thrombocytopenia. Methods The clinical data of 60 AECOPD patients with thrombocytopenia from 2010 to 2014 in our department were retrospectively analyzed. Results Fifty percent did not require special platelet therapies, 30% given glucocorticoids and prophylactic hemorrhage, 15% plus recombinant human interleukin II (GEM) and 5% required further infusion of fresh platelets. For patients with local subcutaneous hemorrhage promptly disable all drugs that may lead to thrombocytopenia. Conclusions Although the mechanism of thrombocytopenia during hospitalization in patients with AECOPD is unclear, the mechanism of drug-induced and infectivity is not clear from the analysis of this group of patients.