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目的研究在室温下葡萄糖氯化钠钾注射液(简称GNK)分别与甲硝唑注射液、替硝唑葡萄糖注射液配伍后的稳定性。方法采用RP-HPLC法分别测定配伍后甲硝唑和替硝唑的含量变化,同时考察配伍溶液的外观、pH值和不溶性微粒的变化。结果在室温下配伍溶液8 h内均无气体或沉淀产生,pH值、不溶性微粒和含量均无明显变化。结论GNK与甲硝唑注射液、替硝唑葡萄糖注射液配伍后8 h稳定,在8 h内可安全应用于临床。
Objective To study the stability of glucose and sodium chloride potassium injection (GNK) at room temperature with metronidazole injection and tinidazole and glucose injection respectively. Methods The contents of metronidazole and tinidazole were determined by RP-HPLC. The appearance, pH value and the changes of insoluble particles were also investigated. Results There was no gas or sediment in the compatible solution at room temperature within 8 h. There was no obvious change in pH value, insoluble particles and content. Conclusions GNK is stable at 8 h after combination with metronidazole injection and tinidazole and glucose injection, and can be safely used in clinic within 8 h.