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目的探讨青霉素联合妇科千金片治疗急性盆腔炎的临床疗效。方法 136例急性盆腔炎患者随机分为观察组和对照组各68例,对照组在常规治疗的基础上给予青霉素400×104U静脉滴注,每日2次;观察组在对照组治疗的基础上给予妇科千金片6片口服,每日3次;10~15 d为1个疗程。比较2组的疗效、症状消除时间和血清中肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和C反应蛋白(CRP)水平。结果观察组总有效率为94.1%,高于对照组的80.9%(P<0.05);观察组的体温恢复正常时间、腹痛消失时间和包块消除时间均显著短于对照组,差异有统计学意义(P<0.01);2组治疗后血清中TNF-α、IL-6、CRP水平均明显下降(均P<0.01),组间比较,差异有统计学意义(P<0.01);2组不良反应发生率无明显差别(P>0.05)。结论青霉素联合妇科千金片治疗急性盆腔炎疗效显著,可以改善患者的免疫功能,安全性好,值得在临床推广。
Objective To investigate the clinical efficacy of penicillin combined with gynecological Qianjin tablets in the treatment of acute pelvic inflammatory disease. Methods One hundred and sixty-six patients with acute pelvic inflammatory disease were randomly divided into observation group (68 cases) and control group (68 cases). The control group was given intravenous infusion of penicillin 400 × 104U twice daily on the basis of routine treatment. On the basis of the control group Give gynecological gold tablets 6 orally, 3 times a day; 10 ~ 15 d for a course of treatment. The curative effect, symptom elimination time, serum TNF-α, IL-6 and C-reactive protein (CRP) levels were compared between the two groups. Results The total effective rate in the observation group was 94.1%, which was higher than that in the control group (80.9%, P <0.05). The body temperature recovery time, the disappearance of abdominal pain and the elimination time of abdominal pain in the observation group were significantly shorter than those in the control group (P <0.01). The levels of TNF-α, IL-6 and CRP in the two groups were significantly decreased after treatment (all P <0.01). There was significant difference between the two groups (P <0.01) No significant difference in the incidence of adverse reactions (P> 0.05). Conclusion Penicillin and gynecology Qianjin tablets treatment of acute pelvic inflammatory disease significant effect, can improve the patient’s immune function, safety, and worth in the clinical promotion.