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目的 探讨益气活血方对动脉粥样硬化（ＡＳ）及动脉结构的影响。方法 ３２只新西兰大白兔随机分为四组：正常对照组、高脂对照组、益气活血预防组及益气活血治疗组，观察时间为二月。治疗前后进行血脂分析，治疗结束取主动脉组织作脂质及钙定量，并对主动脉作病理学检查，测量动脉管壁厚度、内膜厚度、管壁面积、内膜面积及管腔面积。结果１．益气活血方治疗可以降低模型兔血胆固醇、甘油三酯、低密度脂蛋白胆固醇，使动脉内甘油三酯水平显著降低，但对主动脉内钙含量无明显影响。２．益气活血治疗减少模型动物粥样硬化的形成，使内膜面积、厚度减少，但对管腔面积无明显影响。结论 益气活血方具有降低血脂和抑制ＡＳ形成的作用。
Objective To investigate the effect of Yiqi Huoxue Fang on atherosclerosis (AS) and arterial structure. Methods Thirty-two New Zealand white rabbits were randomly divided into four groups: normal control group, high-fat control group, Yiqi Huoxue Prevention Group, and Yiqi Huoxue Treatment Group. The observation time was February. Blood lipid analysis was performed before and after treatment. Aortic tissue was taken at the end of the treatment for lipid and calcium quantification, and the aorta was examined for pathology. The arterial wall thickness, intimal thickness, wall area, intima area, and lumen area were measured. Results 1. Treatment with Yiqi Huoxue Decoction can reduce blood cholesterol, triglyceride, and low-density lipoprotein cholesterol in model rabbits, and reduce arterial triglyceride levels significantly, but has no significant effect on intra-aortic calcium levels. 2. Yiqihuoxue treatment reduced the formation of atherosclerosis in model animals, reduced the intimal area and thickness, but had no significant effect on the lumen area. Conclusion Yiqi Huoxue Decoction can reduce blood lipid and inhibit AS formation.