用内分泌学方法已发现有内分泌活性的垂体瘤过度分泌某种激素,但一直未发现非分泌性垂体瘤的分泌特征。用电子显微镜发现非分泌性垂体瘤细胞浆内似存在着具分泌活性垂体瘤细胞浆所含的那种分泌激素颗粒。虽然这些颗粒分泌的激素现在还不知道,但可根据肿瘤细胞起源的细胞类型、结合肿瘤标记物等使其发光容易辨认。 NSE是存在于神经元及其轴突中的一种糖酵解酶的YY同质异构体。它是测定非分泌性垂体瘤中分泌颗粒的一种生化标记物的候选物。最近研究 Endocrinological methods have been used to detect the secretion of certain hormones by pituitary tumors that have endocrine activity. However, the secretory characteristics of non-secreting pituitary tumors have not been found. The electron microscopy revealed that secretory granules contained in the secretory pituitary tumor cell paste appear to exist in the cytoplasm of non-secreting pituitary tumor cells. Although the secretory hormones of these granules are not known yet, their luminescence can be easily recognized based on the cell type originated from the tumor cells, the binding of tumor markers, and the like. NSE is a YY isoform of a glycolytic enzyme present in neurons and their axons. It is a candidate for the determination of a biochemical marker of secretory granules in nonsecreting pituitary tumors. Recent research