论文部分内容阅读
目的为探讨不同剂量米非司酮对有症状子宫肌瘤的治疗作用及不良反应。方法子宫肌瘤患者120例,随机分成3组,分别予米非司酮片每日口服25mg及12.5mg,连续90d,予米非司酮片每日口服5mg,连续90d,并在用药期间观测不良反应及在用药结束后观测肌瘤体积。结果3组患者肌瘤体积平均缩小无明显差异,但12.5mg及5mg组较25mg组不良反应发生减少。结论小剂量米非司酮对子宫肌瘤治疗作用同较大剂量相似,但发生不良反应较少。
Objective To investigate the different doses of mifepristone on the treatment of symptomatic uterine fibroids and adverse reactions. Methods A total of 120 patients with uterine fibroids were randomly divided into three groups. Mifepristone tablets were orally administered 25 mg and 12.5 mg daily for 90 consecutive days. Mifepristone tablets were orally administered 5 mg daily for 90 days and were observed during the treatment Adverse reactions and observation of myoma volume after treatment. Results There was no significant difference in the average reduction of fibroids between the three groups, but the adverse reactions in 12.5mg and 5mg groups were less than those in 25mg group. Conclusion The low dose of mifepristone on the treatment of uterine fibroids with higher dose similar, but less adverse reactions.