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目的 研究胃癌瘤体中血管细胞粘附分子 (VCAM 1)对胃癌的血管生成、生长、转移的影响。方法 对 30例胃癌 ,8例胃溃疡 ,10例正常人标本进行了免疫组化染色、图像分析 ,分析瘤体VCAM 1的表达与胃癌病理参数的关系。结果 VCAM 1不仅表现在胃癌血管内皮细胞上高表达 ,在胃癌细胞膜上也有表达 ,而且VCAM 1的表达强度表达率与胃癌的血管的生成和转移有关。结论 VCAM 1在胃癌的血管生成、瘤细胞转移中可能起到重要作用 ,其促进了胃癌肿瘤血管的形成。
Objective To study the effect of vascular cell adhesion molecule (VCAM 1) on angiogenesis, growth and metastasis of gastric cancer. Methods Immunohistochemical staining and image analysis were performed on 30 cases of gastric cancer, 8 cases of gastric ulcer and 10 cases of normal persons. The relationship between the expression of VCAM 1 and the pathological parameters of gastric cancer was analyzed. Results VCAM 1 not only showed high expression on gastric vascular endothelial cells, but also on gastric cancer cell membrane. Moreover, the expression of VCAM 1 expression intensity was related to the formation and metastasis of gastric cancer. Conclusion VCAM 1 may play an important role in angiogenesis and tumor cell metastasis of gastric cancer, which promotes the formation of gastric cancer tumor blood vessels.