目的观察大剂量吗啡注射液对重度疼痛的晚期癌症患者的镇痛效果及不良反应。方法对30例晚期癌痛患者给予大剂量吗啡注射液止痛泵维持镇痛治疗,剂量为5mg·h-1~15mg·h-1,随镇痛效果调整用药量。结果显效率为100%,未出现呼吸抑制。结论大剂量吗啡具有安全、镇痛效果稳定等优点,能显著提高患者的生活质量。 Objective To observe the analgesic effect and adverse reactions of high-dose morphine injection in patients with advanced cancer with severe pain. Methods Thirty patients with advanced cancer pain were given high-dose morphine injection analgesia to maintain analgesia. The dosage was 5 mg · h-1 ~ 15 mg · h-1, and the dosage was adjusted with the analgesic effect. Results showed that the efficiency was 100%, no respiratory depression. Conclusion High-dose morphine has the advantages of safety, stable analgesic effect, and can significantly improve the quality of life of patients.