目的　探讨内源性一氧化碳 (CO)在新生儿败血症中的变化及其临床意义。方法　测定新生儿败血症患儿和正常新生儿的血浆CO水平 ,并结合血浆一氧化氮 (NO)水平进行对比分析。结果　新生儿败血症患儿血浆CO和NO水平均显著高于正常对照组 (P <0 .0 5) ,且CO与NO显著相关 (P <0 .0 5)。结论　CO作为一种新的内源性介质参与了新生儿败血症的病理生理过程 Objective To investigate the changes of endogenous carbon monoxide (CO) in neonatal sepsis and its clinical significance. Methods Plasma CO levels in neonates with sepsis and normal neonates were measured and compared with the levels of plasma nitric oxide (NO). Results The levels of plasma CO and NO in neonatal septicemia were significantly higher than those in normal control group (P <0.05), and CO and NO were significantly correlated (P <0.05). Conclusion As a new endogenous mediator, CO participates in the pathophysiological process of neonatal sepsis