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目的探讨正常晚孕妇女和妊娠高血压综合征(妊高征)患者血浆中纤维蛋白原(FIB)和D-二聚体(D-D)水平及其临床意义。方法采用Sysm exC A-700 0全自动血凝仪检测50 0例正常晚期妊娠孕妇(正常晚孕组)、2 0 0例妊高征孕妇(妊高征组)和100例健康育龄期非妊娠女性(正常未孕组)血浆中FIB和D-D水平。结果正常晚孕妇女、妊高征患者血浆中FIB、D-D水平分别高于健康未孕妇女,妊高征患者的FIB、D-D水平高于正常晚孕妇女,两组比较差异有统计学意义(P<0.01)。结论正常临产孕妇处于高凝状态,妊高征患者血栓前状态更明显。检测FIB、D-D对妊高征的诊断、预后评估有重要的应用价值。
Objective To investigate the plasma levels of fibrinogen (FIB) and D-dimer (D-D) in patients with normal pregnancy and pregnancy induced hypertension (PIH) and their clinical significance. Methods Sysm exC A-700 0 automatic coagulation analyzer was used to detect 50 0 cases of normal late pregnant women (normal pregnancy group), 200 cases of pregnancy induced hypertension (PIH) and 100 healthy non-pregnant women of childbearing age Plasma FIB and DD levels in women (normal nonpregnant group). Results The plasma levels of FIB and DD in normal pregnant women and PIH patients were significantly higher than those in healthy pregnant women, respectively. The FIB and DD levels in patients with PIH were higher than those in normal pregnant women (P <0.05), and the differences between the two groups were statistically significant (P <0.01). Conclusion Normal pregnant women in hypercoagulable state, PIH patients prethrombotic state is more obvious. Detection of FIB, D-D on the diagnosis of pregnancy-induced hypertension, prognosis assessment has important application value.