Temporal epigenetic modifications differentially regulate ES cell-like colony formation and maturati

来源 :干细胞探索(英文) | 被引量 : 0次 | 上传用户：wangliubaobao

【摘要】

：

Human somatic cells can be directly reprogrammed to induced pluripotent stem (iPS) cells by forced expression of the transcription factors Oct4, Sox2, and eithe

【作者】

：

Jong S. Rim Karen L. Strickler

【机构】

：

DepartmentofAnatomy&,CellBiology,NuPotential,StemCellBiologyLaboratory

【出处】

：

干细胞探索(英文)

【发表日期】

：

2012年2期

【关键词】

：

EPIGENETIC Modification SOMATIC Cell REPROGRAMMING Epigenetic Modification Somat

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Human somatic cells can be directly reprogrammed to induced pluripotent stem (iPS) cells by forced expression of the transcription factors Oct4, Sox2, and either Klf4 and cMyc or Nanog and Lin28, using virus-based systems. However, low reprogramming effic

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Temporal epigenetic modifications differentially regulate ES cell-like colony formation and maturati

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