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本文介绍一种简单、快速、重复性好的高脂血症模型。静脉注射Trit on 400mg/kg1次,3h后血脂开始升高,12h左右达高峰。β-LP24h后逐渐恢复正常,TC于72h仍高于对照。β-LP和TC都有一个明显、稳定的上升相和减退相。皮下和腹腔注射亦能使血清TC升高,但所需剂量较大或所需时间较长。此模型既可观察药物对血清脂质上升阶段的影响,也可检测药物对血清脂质减退程度的影响。用本法筛选药物1～2天即可得出结果。缺点是不能反映对外源性胆固醇吸收的影响。
This article describes a simple, fast and repeatable model of hyperlipidemia. Intravenous Trit on 400mg / kg 1 times, 3h after the blood lipids began to rise, reaching a peak around 12h. β-LP24h gradually returned to normal, TC is still higher than the control at 72h. Both β-LP and TC have a clear, steady rising and falling phase. Subcutaneous and intraperitoneal injection can also raise serum TC, but the required dose is larger or takes longer. This model can not only observe the effect of drugs on the phase of serum lipid increase, but also detect the effect of drugs on the degree of serum lipid decline. Use this method screening drugs 1 to 2 days to draw the results. The disadvantage is that it does not reflect the effect on exogenous cholesterol absorption.