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目的考察不同缺血期对大鼠缺血再灌注过程脑血流的影响。方法通过激光散斑成像技术(LSCI)检测大鼠大脑中动脉不同栓塞时间后,对再灌注过程中脑血流的影响,并对再灌注过程中的低灌注状态、无复流现象、血流流速及管径变化进行研究分析。结果 2 h的栓塞后,大鼠脑部血流量趋向低灌注状态,约为栓塞前血流基值的(35±10)%;栓塞时间越长,无复流现象越多;在再灌注期间,缺血2 h组的血流比0.5 h组的低灌注水平低10%。结论长时间的脑缺血期再灌注过程可能是造成脑损伤程度加重的主要原因之一。LSCI可应用于脑部血流实时监测,操作简便,成像灵敏、稳定,结果可靠。
Objective To investigate the effect of different ischemic periods on cerebral blood flow during ischemia-reperfusion in rats. Methods The cerebral blood flow during reperfusion was detected by laser speckle imaging (LSCI), and the effects of low perfusion, no-reflow phenomenon, blood flow Flow rate and diameter change research and analysis. Results After 2 h of embolization, the cerebral blood flow in rats tended to be low perfusion, which was about (35 ± 10)% of that before embolization. The longer the embolization time, the more no-reflow phenomenon. During the reperfusion period , Blood flow in ischemic 2 h group was 10% lower than that in 0.5 h group. Conclusion Long-term cerebral ischemia reperfusion process may be one of the main causes of brain injury. LSCI can be used in real-time monitoring of blood flow in the brain, easy to operate, sensitive imaging, stable and reliable results.