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在子宫肌瘤中,雌、孕激素受体及其mRNA表达数量均多于正常子宫肌层。因此患子宫肌瘤的绝经后妇女雌激素替代治疗(HRT)受到限制。为观察人工合成具有弱雌、孕、雄激素特性的利维爱(Tibolone)对子宫肌瘤的影响,对自然绝经1年以上,至少存在20mm子宫肌瘤1个;无症状,无HRT禁忌的40例妇女进行研究。患者受试前3个月无任何药物使用史;血FSH>35mIU/ml,E_2<30pg/ml;9HD的ATL超声测量治疗前后子宫肌瘤的大小,并计算体积。随机分为对照组及治疗组各20例,两组的体
In uterine fibroids, the number of estrogen and progesterone receptors and their mRNA expression were more than normal myometrium. Therefore, postmenopausal women suffering from uterine fibroids are limited by estrogen replacement therapy (HRT). To observe the effect of artificial synthesis of Tibolone with weak estrogen, pregnancy, and androgen properties on uterine fibroids, for natural menopause for more than one year, there is at least one uterine fibroid with 20mm; no symptoms, no HRT contraindications 40 women were studied. The patient had no history of drug use for the first 3 months of the study; blood FSH> 35 mlU/ml, E_2 <30 pg/ml; 9HD ATL ultrasonography measured the size of the uterine fibroid before and after treatment and calculated the volume. Randomly divided into control group and treatment group of 20 cases, two groups of body