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第二代氨基糖苷类抗生素妥布拉霉素(Tobramycin)是世界临床最广泛使用的氨基糖苷类抗生素之一,是美国礼来制药公司1967年从黑暗链霉菌(S.tenebrarius)发酵液中分离到的尼拉霉素复合物(Nebramyc-in,以前曾称为Tenebrimycin和Tenemyc-in)组份6。美国最初报道时,黑暗链霉菌产生的尼拉霉素复合物至少有1、1’、2、3、4、5、6等7个组份,其中组份2、4、5、6是主要组份。1973年用改进的提取和分离方法证明:黑暗链霉菌产生的尼拉霉素复合物中的主要组份是2、4、5三个组份,该产生菌不直接产生尼拉霉素组份5(卡那霉素B)和组
The second generation of aminoglycoside antibiotics Tobramycin is one of the most widely used aminoglycoside antibiotics in the world and is separated from the S.tenebrarius fermentation broth by Eli Lilly and Company in 1967 (Nebramyc-in, formerly known as Tenebrimycin and Tenemyc-in). When initially reported in the United States, the Streptomyces hygroscopicus produced at least 1, 1, 2, 3, 4, 5, 6 and 7 other components, of which components 2, 4, Component. 1973 with improved extraction and separation methods proved: Streptomyces dark Streptomyces complex produced by the main component of 2,4,5 three components, the production of bacteria does not directly produce the component of the nikkomycin 5 (kanamycin B) and group